Applying differential pressure drainage by positive and negative pressure shift(MI-E),to enhance respiratory muscle strength and efficacy and obtain fully pulmonary re-expansion;mobilize the retained mucus on bronchioli terminales to central airways and outside body by cilia inverse brush simultaneously;improve pulmonary circulation and blood gases exchange,prevent pulmonary atelectasis.Clearance efficacy of pulmonary secretions caused by various reasons.AutoCough system prescribed for therapy of pulmonary secretions clearance obstacles caused by various reasons,including COPD,severe case,tracheal intubation,after tracheotomy,feeble expiration,pulmonary fibrosis,progressive muscular atrophy,Guillain-Barre syndrome,lateral sclerosis of spinal cord,Motor Neuron Disease(MND),and for patients in ICU,after lung transplantation and other post-operation patients to maintain normal lung function.In clinical research,AutoCough system proved to:Improve pulmonary secretions removal ability.Enhance patients tolerance of activity.Stabilize or improve lung function.Reduce the risk of airway damage and respiratory complications.Very high degree of patients satisfaction and reuse,cut down therapy cost.