Fetal free DNA RhD genotyping Kit(PCR-Taqman)
SUPER021-002CF-024
This kit is used for the RhD blood group genotyping detection of fetal free DNA of RhD negative, i.e.RhD whole gene deletion, RhD-CE (2-9) - D and DVa (Hus), maternal peripheral blood, including exons 5, 7, and 10 of the RhD gene. The kit could assist in the diagnosis of fetal hemolytic disease caused by maternal fetal RhD blood group incompatibility.

Hemolytic disease of the fetus and newborn (HDFN) is mainly caused by maternal infant ABO blood group system incompatibility in China, with Rh blood group system related HDFN accounting for 1.91%^[1]. However, Rh blood group D antigen is the most common cause of moderate to severe HDFN. When RhD negative mothers conceive RhD positive fetuses, the fetal D antigen stimulates the mother to produce anti-D antibodies, which combine with fetal D antigen to cause HDFN. Currently, for RhD negative pregnant women who produce anti-D, injection of anti-D immunoglobulin is administered to block RhD positive red blood cells from the fetus to prevent HDFN. By detecting free fetal DNA in the peripheral blood of pregnant women, non-invasive prenatal testing can be performed on the RhD blood type of fetuses of RhD negative pregnant women for providing reference for clinical diagnosis.