The solution contains 10,000 units/mL penicillin and 10,000 μg/mL streptomycin. Antibiotics - Penicillin and streptomycin are effective combined antibacterial agents against Gram-positive and Gram-negative bacteria and can be used to prevent bacterial contamination of cell cultures. Penicillin was originally purified from the fungus Penicillium and its mechanism of action is to directly interfere with bacterial cell wall synthesis and indirectly by triggering the release of enzymes that further alter the cell wall. Streptomycin was originally purified from Streptomyces griseus. Its mechanism of action is to bind to the 30S subunit of bacterial ribosomes, thereby inhibiting protein synthesis, leading to the death of sensitive bacteria.

A wide range of antibiotics and antifungals are available in both powder and liquid forms. Learn more about these types of products:

•Cell culture antibiotics
•Screening antibiotics (including recommended working concentrations)

Learn more about the use of antibiotics and antifungals in cell culture and review guidance on eliminating culture contamination.