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These professional wide-mouth tips are designed for researchers working with large molecules such as genomic DNA, and are particularly important when transferring fragile cell samples such as macrophages, hybridomas, and hepatocytes. When these types of samples are forced through the narrow tip holes of conventional tips, they are subjected to mechanical shear forces that can cause damage and fragmentation of the transferred cells. This usually results in a decrease in plate culture ability and cell viability. Our wide-bore blunt-end tips eliminate cell shear and flow resistance, making them ideal for extremely viscous materials.