Nissl stain is a standard histological method used to visualize neurons in the brain and spinal cord. Nissl substance is composed of ribosomal RNA associated with rough endoplasmic reticulum in neuronal perikarya and dendrites. It is redistributed in the cell body of injured or regenerated neurons and provides markers for the physiological state of neurons. Our NeuroTrace 435/455 Blue Fluorescent Nissl Stain is selective for Nissl substances characteristic of neurons and offers better performance than traditional histology stains such as toluidine blue or cresyl violet. Higher sensitivity.