Thermo Scientific Pierce Premium TCEP-HCl is our highest quality formulation of this disulfide reducing agent, specifically designed to Special characterization is performed for applications where product integrity and risk mitigation are critical.

Features of Premium TCEP-HCl:

•TCEP—a thiol-free, odorless and powerful reducing agent for cleaving disulfide bonds
• High Quality—confirms identity and purity through multiple tests, including quantitative NMR
• Product Integrity—enhanced testing beyond standard levels and characterization levels
• Batch Retention—Retain an adequate supply of past batches to ensure future process testing
• Change Management—Change Control Notification (CCN) ) Services
• Consistent Manufacturing—Batch-specific manufacturing documentation review

Premium Grade TCEP-HCl covers (a) more of the Analytical testing and product characterization, (b) greater batch-specific information and quality assurance reviews, (c) bulk batch sample retention and (d) change control notifications to provide clearer quality and product support. TCEP-HCl is a high-purity, crystalline tris(2-carbonylethyl)phosphate hydrochloride. It is a thiol-free compound that can effectively reduce protein and peptide disulfide bonds while being odorless and stable. . TCEP can selectively and thoroughly reduce the more stable water-soluble alkylated disulfides over a wide pH range.

Advantages of TCEP-HCl over other reducing agents:
•Odorless—Unlike DTT or BME, TCEP is odorless and therefore can be used in Conveniently restore on the laboratory bench.
•Stable in Air—The inherent stability of the TCEP groups eliminates the need to take any special precautions to avoid oxidation when handling, using, or storing TCEP.
•Efficient—For most applications, 5 to 50 mM TCEP provides sufficient molar volume to efficiently reduce peptide or protein disulfide bonds within minutes at room temperature.
•Compatible—Using TCEP, most applications (e.g., Histidine-tagged protein purification, maleimide coupling, etc.) do not require prior removal of the reducing agent.

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Pierce™ TCEP-HCl