Thermo Scientific Pierce EMCS is an amine-to-thiol cross-linker containing NHS ester and maleimide reactive groups clusters, located at opposite ends of a medium-length spacer arm (9.4 Å).

Features of EMCS:

•Reactive groups: NHS Ester&Maleimide
•Can react with the following groups:Amino and thiol
• Aliphatic spacer series C6 homologues include AMAS, BMPS, GMBS and EMCS
•NHS The ester terminal is coupled with the primary amine at pH 7-9 to form a stable amide bond
•Maleimide reacts with the -SH group at pH 6.5-7.5 to form a stable thioether bond< br>•Non-cleavable
•Insoluble in water (dissolve in DMF or DMSO first); compatible with Sulfo-EMCS< /a> Comparable
• Increased coupling of spheres compared to GMBS
• Short aliphatic spacers less likely to elicit an immune response

Product Reference:
Crosslinking Agent Application Guide--Search for the latest references for this product