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By using smaller resin particles, higher resolutions can be achieved at standard flow rates Generating column backpressure in excess of 3000 psi. Running this column under standard conditions requires the use of a high-pressure IC (HPIC™) system, such as the Thermo Scientific™ Dionex™ ICS-6000 HPIC™ or Dionex™ Integrion™ HPIC™ system. Used in conjunction with a pulsed amperometric detection (PAD) system, non-derivatized carbohydrate compounds can be directly quantified from very small sample preparations.