Thermo Scientific Pierce Phosphatase Inhibitor Mini Tablets completely protect cell lysates and biological samples from a broad spectrum of Dephosphorylation by serine and threonine phosphatases.

Pierce Phosphatase Inhibitor Mini Tablets Features:
•Affordable—More cost-effective than other commercially available formulations
• Formulation improvements b>—Tablets rapidly dissolve into clear solutions
• Comprehensive—Tablets inhibit acid, base, and protein phosphatases
• Compatible—Compatible with domestic or Commercially available cell lysis reagents for use with Thermo Scientific protein assays

Pierce Phosphatase Inhibitor Mini Tablets protect phosphoproteins from dephosphorylation by serine/threonine phosphatases and tyrosine phosphatases. Each phosphatase inhibitor tablet contains sodium fluoride, sodium orthovanadate, sodium pyrophosphate, and beta-glycerol phosphate for broad-spectrum inhibition of phosphatase activity. Tablets are stable for 12 months at 4°C and each tablet is sufficient to treat 10 mL of solution. Pierce Phosphatase Inhibitor Tablets are suitable for use with any cell or tissue extract to preserve protein phosphorylation for downstream applications.

Protein phosphorylation and dephosphorylation states often serve as molecular on/off switches for key regulators in intracellular biological pathways, including signal transduction, cell division, and apoptosis. To effectively study phosphorylation signaling events, endogenous phosphatases must be inactivated to prevent their uncontrolled activity after cell lysis. Pierce Phosphatase Inhibitor Tablets preserve phosphoprotein modifications by significantly reducing endogenous acid, base, and protein phosphatase activities.

Pierce Phosphatase Inhibitor Mini Tablets are compatible with most detergent-based cell lysis reagents, including Pierce Cell Lysis Buffer. If incompatibility occurs, the inhibitor components can be removed by dialysis or desalting before performing these procedures.

To use Pierce Phosphatase Inhibitor Mini Tablets, simply dissolve 1 tablet in 10 mL of buffer or lysate. Pierce Phosphatase Inhibitor Mini Tablets do not contain protease inhibitors. If necessary, protease inhibitors (such as Pierce Protease Inhibitor Tablets) can be added together with the phosphatase inhibitor tablets.

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