Purified Saccharomyces cerevisiae RNA is suitable for use as a co-precipitating agent in nucleic acid precipitation. It cannot be used in reactions inhibited by exogenous RNA and is the cheapest source of high-quality co-precipitating reagent. This total RNA preparation is supplied as 0.5 mL per tube of a 5 mg/mL solution in distilled water (diethyl pyrocarbonate treated). It is typically used at a working concentration of 10–20 μg/mL.

What is a coprecipitant?
Co-precipitating agents are inert substances that aid in nucleic acid recovery during ethanol precipitation. Although they can be used to precipitate large amounts of nucleic acid, they are also essential for the quantitative recovery of small amounts of nucleic acid in dilute solutions. Generally, such molecules are used only to reveal the granular precipitate after centrifugation.