Ambion® Molecular Biology Grade, 5 M Ammonium Acetate Solution is supplied in 500 mL bottles. This solution is certified RNase-free, economical, and ready to use. Manufacturing products for use with RNA is challenging due to the ubiquity of RNases. Ambion® nuclease-free reagents and buffers are manufactured in facilities that are specifically designed to prevent the introduction of nucleases. Highly sensitive RNase detection is performed at several different stages of the manufacturing process to ensure optimal quality. The reagents are rigorously tested for nonspecific contaminating endonucleases, exonucleases, and RNase activity.