Lipofectamine CRISPRMAX Cas9 Transfection Reagent is the first liposomal nanoparticle transfection optimized for CRISPR-Cas9 protein delivery Reagents. This is a suitable high-throughput, cost-saving alternative to electroporation.

TrueCut Cas9 protein v2 and TrueGuide Synthetic gRNAWhen used in combination, it provides:
•Displayed cleavage efficiency—measured in over 20 cell types, including iPSC, mESC, N2A, CHO, A549, HCT116, HeLa, HEK293, and several others Type
• Low cytotoxicity – reduces the number of cells needed to start an experiment
• Suitable for high throughput – ideal delivery solution in 96-well format
• Cost savings – both in terms of single reaction cost and initial investment
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Achieve high transfection efficiency in novel genome editing applications
Lipofectamine CRISPRMAX Transfection Reagent increases the likelihood of successful cleavage and recombination, especially when combined with our TrueCut Cas9 Protein v2 When used with TrueGuide synthetic gRNA. This ultimately maximizes the efficiency of performance genetic modification.

Improve experimental results with TrueCut Cas9 Protein v2
Unlike CRISPR plasmids or Cas9 mRNA, using the Cas9 gene provides superior cleavage efficiency in primary and stem cells. It eliminates the need for transcription or translation of the payload, eliminates the risk of genomic integration, and is cell cycle independent.