Ambion® Molecular Biology Grade, 0.5 M EDTA (pH 8.0) solution is supplied in 100 mL bottles. This solution is certified RNase-free, cost-effective, and ready-to-use. Because RNase is so ubiquitous, producing products for use with RNA is extremely difficult. Ambion®'s nuclease-free reagents and buffers are manufactured in multiple facilities specifically designed to prevent the introduction of nucleases. Highly sensitive RNase detection is performed at several different stages of the production process to ensure optimal quality. These reagents have been rigorously tested for non-specific contaminating endonuclease, exonuclease and RNase activity.